Helicobacter pylori strain APR133

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain APR133 is a Gram-negative bacterium characterized by its spirilla shape and a tendency to exist as single cells. This strain thrives optimally at a temperature of 37.0°C, which aligns with the physiological conditions found within the gastric environment of its hosts. As a microaerophilic organism, H. pylori strain APR133 requires reduced levels of oxygen for growth, indicating its adaptation to the oxygen-limited niches typically found in the stomach lining. The host-associated habitat of H. pylori strain APR133 suggests a close relationship with its host, where it may play a role in the complex microbiome of the gastrointestinal tract. The microaerophilic nature of this strain may provide insights into its survival strategies within the acidic gastric niche, where it can evade the harsh conditions and compete effectively against other microbial inhabitants. Understanding the specific traits of H. pylori strain APR133 can contribute to broader research on host-microbe interactions and the ecological dynamics within the stomach, particularly in terms of its adaptation mechanisms and potential roles in health and disease.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain APR133

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain APR133
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain APR133


Gene Summary

Adenine Count

490787 bp

Thymine Count

500036 bp

Guanine Count

313828 bp

Cytosine Count

320920 bp

Genome Length

1625889 bp

Protein-coding Genes

1460 genes

Non-Coding Genes

42 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
smi1/knr4 family proteinDD777_00005Not AvailablePositive1 - 722579.16
hypothetical proteinDD777_00010Not AvailablePositive74 - 42113824.3
16s ribosomal rnaNot AvailableNot AvailablePositive433 - 1941Not Available
urease accessory proteinDD777_00020Not AvailableNegative2935 - 373229710.9
urease accessory protein uregDD777_00025Not AvailableNegative3732 - 433121955.7
urease accessory protein urefDD777_00030Not AvailableNegative4360 - 512428616.5
urease accessory protein ureeDD777_00035Not AvailableNegative5147 - 552413928.0
urease accessory protein urefDD777_00040Not AvailableNegative5525 - 597817042.7
urease accessory protein ureeDD777_00045Not AvailableNegative6008 - 652019222.4
acid-activated urea channelDD777_00050Not AvailableNegative6522 - 710921609.6

Displaying genes 1 – 10 of 1502 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 66 in total