Streptomyces griseus subsp. griseus NBRC 13350

The genus Streptomyces consists of soil and water Gram positive filamentous bacteria well known for their ability to produce complex secondary metabolites including many antibiotics. Additionally they undergo complex multicellular development, with spores germinating to form a branched, multinucleoid substrate mycelium, which then produces an aerial mycelium which septates into uninucleoid spores. Streptomyces is also unusual in having linear chromosomes with terminal inverted repeats with terminal proteins covalently bound to their 5' ends.Streptomycin, the first aminoglycoside antibiotic, was discovered more than 60 years ago, is still used to treat tuberculosis and is produced commercially by S.griseus. Analysis of the genome of strain JCM 4626 / NBRC 13350 indicates the presence of 34 gene clusters or genes for the biosynthesis of known or unknown secondary metabolites. (HAMAP: STRGG)