Campylobacter concisus 13826

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Campylobacteraceae

Genus

Campylobacter

Description

Campylobacter concisus 13826 is a gram-negative, curved bacillus that thrives optimally at moderate temperatures, classifying it as a mesophile. This microbe is a chemoheterotroph, relying on organic compounds for energy and carbon, and exhibits microaerophilic behavior, meaning it requires lower levels of oxygen than what is present in the atmosphere for optimal growth. Campylobacter concisus is primarily associated with the human gastrointestinal tract, where it can be found in the oral cavity and intestines, but has also been identified in other body sites, including the respiratory tract and genitourinary system. The gram-negative nature of Campylobacter concisus is indicative of its double membrane structure, featuring an outer membrane composed of lipopolysaccharides, which can help evade the host immune response. Its curved bacillus shape enhances motility, allowing this microorganism to navigate through viscous environments like intestinal mucus. As a mesophile, it thrives at temperatures around 37°C, typical of the human body, which supports its role as a pathogen. The chemoheterotrophic lifestyle of Campylobacter concisus relies on carbohydrates and amino acids for energy, underscoring its adaptability to the nutrient-rich environments of the human gut. Its microaerophilic requirement highlights its unique metabolic adaptations, allowing it to flourish in low-oxygen environments while potentially competing with other gut flora. Campylobacter concisus has garnered attention for its association with gastrointestinal diseases, particularly inflammatory bowel disease. Emerging research suggests that dysbiosis involving this microbe may play a role in gut health and disease progression, paving the way for further studies into its pathogenic mechanisms and potential therapeutic targets. Its ability to persist in various human body sites and adapt to different environments underscores its significance in microbial ecology and human health.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyCampylobacteraceae
GenusCampylobacter
SpeciesCampylobacter concisus
Strain13826

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementChains - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Campylobacter concisus 13826

Accession NumberNC_009796.1

Gene Summary

Adenine Count

5880 bp

Thymine Count

5071 bp

Guanine Count

2844 bp

Cytosine Count

2662 bp

Genome Length

16457 bp

Protein-coding Genes

23 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

3

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
replication initiation proteinCCC13826_RS10450Not Available+349 - 130837856.6
hypothetical proteinCCC13826_RS10455Not Available+1408 - 182715024.2
cj0814 family flagellar-dependent secreted proteinCCC13826_RS10460Not Available+1881 - 302343359.2
spore coat protein cothCCC13826_RS10465Not Available+3134 - 369720704.3
hypothetical proteinCCC13826_RS10470Not Available+3697 - 398411042.2
hypothetical proteinCCC13826_RS10475Not Available+4010 - 456720148.0
cj0814 family flagellar-dependent secreted proteinCCC13826_RS10480Not Available+4621 - 582045022.0
hypothetical proteinCCC13826_RS10485Not Available+6048 - 62788323.6
hypothetical proteinCCC13826_RS10490Not Available+6281 - 672716951.2
hypothetical proteinCCC13826_RS10495Not Available-6752 - 69708499.0

Displaying genes 1 – 10 of 2133 in total

Pathways

5 pathways

Metabolites

11 records
Metabolite IDMetabolite nameStructureCAS number
BASm00041244-(gamma-L-glutamylamino)butanalC9H16N2O4Chemical structure of 4-(gamma-L-glutamylamino)butanalNot available
Average216.2343Da
Monoisotopic216.11100701Da
BASm0014032Acetic acidC2H4O2Chemical structure of Acetic acid64-19-7
Average60.052Da
Monoisotopic60.021129372Da
BASm0014033AmmoniaH3NChemical structure of Ammonia7664-41-7
Average17.0305Da
Monoisotopic17.026549101Da
BASm0014042Oxoglutaric acidC5H6O5Chemical structure of Oxoglutaric acid328-50-7
Average146.0981Da
Monoisotopic146.021523302Da
BASm0017263NADPC21H29N7O17P3Chemical structure of NADP53-59-8
Average744.4129Da
Monoisotopic744.083277073Da
BASm0017275S-AdenosylmethioninamineC14H23N6O3SChemical structure of S-Adenosylmethioninamine22365-13-5
Average355.436Da
Monoisotopic355.155234322Da
BASm00172855-MethylthioriboseC6H12O4SChemical structure of 5-Methylthioribose23656-67-9
Average180.222Da
Monoisotopic180.045629562Da
BASm00174514-(Glutamylamino) butanoateC9H16N2O5Chemical structure of 4-(Glutamylamino) butanoate5105-96-4
Average232.2337Da
Monoisotopic232.105921632Da
BASm0017814Ferricytochrome cC42H68O13Chemical structure of Ferricytochrome c9007-43-6
Average780.993Da
Monoisotopic780.46599225Da
BASm0019023Ferrocytochrome cC5H12Chemical structure of Ferrocytochrome cNULL
Average72.1488Da
Monoisotopic72.093900384Da

Displaying 1–10 of 11 metabolites