Campylobacter lari RM2100

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Campylobacteraceae

Genus

Campylobacter

Description

Campylobacter lari RM2100 is a gram-negative, spiral-shaped bacterium characterized as a microaerophile and a chemoheterotroph, which thrives optimally at temperatures around 42°C. This microorganism is commonly found in various body sites of different species, particularly in the intestines of birds, mammals, and reptiles, where it plays a role in the gut microbiome. As a gram-negative organism, C. lari possesses a thin peptidoglycan layer surrounded by an outer membrane containing lipopolysaccharides, giving it distinctive staining properties. Its spiral shape and motility, facilitated by a single polar flagellum, enable it to navigate the viscous environments of intestinal tracts, contributing to its virulence mechanisms. Microaerophilic in nature, C. lari requires reduced levels of oxygen for optimal growth, making it particularly well-suited to the anaerobic conditions found within the intestines. This oxygen dependency is crucial for its metabolic processes, as it relies on the fermentation of organic compounds as a primary energy source, classifying it as a chemoheterotroph. Notably, C. lari has been associated with gastrointestinal illnesses in humans, particularly through the consumption of contaminated water or undercooked poultry. Its pathogenic potential is underlined by its ability to evade the host immune response and adhere to intestinal epithelial cells, leading to inflammation and infection. Moreover, this microbe has garnered attention in research for its unique genetic and biochemical properties, which may offer insights into the broader Campylobacter genus, paving the way for novel therapeutic approaches to combat Campylobacter-related infections. The study of C. lari RM2100 emphasizes the importance of understanding microbial adaptation and survival strategies within diverse ecological niches.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyCampylobacteraceae
GenusCampylobacter
SpeciesCampylobacter lari
StrainRM2100

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Campylobacter lari RM2100
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatMultiple
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementChains - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Campylobacter lari RM2100


Gene Summary

Adenine Count

17262 bp

Thymine Count

16528 bp

Guanine Count

6516 bp

Cytosine Count

5895 bp

Genome Length

46201 bp

Protein-coding Genes

44 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
chromosomal replication initiator protein dnaaCLA_RS00010Not Available+1 - 132950889.8
dna polymerase iii subunit betaCLA_RS00015Not Available+1462 - 252941072.6
dna topoisomerase (atp-hydrolyzing) subunit bCLA_RS00020Not Available+2539 - 485787403.2
adenosine deaminaseCLA_RS00025Not Available+4866 - 585838100.3
hypothetical proteinCLA_RS00030Not Available+5855 - 685639337.0
preq(1) synthaseCLA_RS00035Not Available+6832 - 721514942.1
sulfite oxidaseCLA_RS00040Not Available+7387 - 863746663.8
hypothetical proteinCLA_RS00045Not Available+8640 - 897512550.3
outer membrane beta-barrel proteinCLA_RS00050Not Available+9018 - 966224261.6
alkylphosphonate utilization proteinCLA_RS00055Not Available+9672 - 98817489.22

Displaying genes 1 – 10 of 1639 in total

Metabolites

1540 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm0001661Cu(2+)CuChemical structure of Cu(2+)7440-50-8
Average63.546Da
Monoisotopic62.929601079Da
BASm00016962-heptyl-3-hydroxy-4(1H)-quinoloneC16H21NO2Chemical structure of 2-heptyl-3-hydroxy-4(1H)-quinoloneNot available
Average259.349Da
Monoisotopic259.15722892Da
BASm0001808corynebactinC39H42N6O18Chemical structure of corynebactinNot available
Average882.789Da
Monoisotopic882.2555585Da
BASm0002593(2E)-dodecenoyl-CoAC33H52N7O17P3SChemical structure of (2E)-dodecenoyl-CoA1066-12-2
Average943.789Da
Monoisotopic943.2353235Da
BASm0002644(9Z,12Z)-octadecadienoyl-CoAC39H62N7O17P3SChemical structure of (9Z,12Z)-octadecadienoyl-CoA6709-57-5
Average1025.94Da
Monoisotopic1025.31577Da
BASm0002963meso-2,6-diaminoheptanedioateC7H14N2O4Chemical structure of meso-2,6-diaminoheptanedioate922-54-3
Average190.1971Da
Monoisotopic190.0953569Da

Displaying 1–10 of 1540 metabolites