Corynebacterium diphtheriae NCTC 13129

Gram-positiveRodNon-motileAerobe

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Mycobacteriales

Family

Corynebacteriaceae

Genus

Corynebacterium

Description

Bacteria from genus Corynebacterium are Gram-positive, nonmotile rods. C.diphtheriae produces the diphtheria toxin, which is usually encoded by a bacteriphage or by an integrated prophage as in this strain. Diphtheria is an acute disease that usually affects the tonsils, throat, nose and/or skin. It is passed from person to person by droplet transmission, usually by breathing in diphtheria bacteria after an infected person has coughed or sneezed. It can lead to breathing problems, heart failure, paralysis and sometimes death. (HAMAP: CORDI)

Taxonomy

Kingdom	Bacillati
Phylum	Actinomycetota
Class	Actinomycetes
Order	Mycobacteriales
Family	Corynebacteriaceae
Genus	Corynebacterium
Species	Corynebacterium diphtheriae
Strain	NCTC 13129

Profile

Physiology
Gram staining properties	Positive
Shape	Rod
Mobility	No
Flagellar presence	Yes
Number of membranes	1

Image source: Wikipedia/Wikimedia

Ecology, Host, and Life Cycle
Oxygen requirements	Aerobe
Optimal temperature	37
Temperature range	Mesophilic
Habitat	Multiple
Biotic relationship	Not Available
Host(s)	Not Available
Cell arrangement	Not Available
Sporulation	Not Available
Energy source	Not Available
Pathogenicity	Yes

Genome Summary

Corynebacterium diphtheriae NCTC 13129

NC_002935.2

Gene Summary

Adenine Count

578357 bp

Thymine Count

579393 bp

Guanine Count

665651 bp

Cytosine Count

665234 bp

Genome Length

2488635 bp

Protein-coding Genes

2243 genes

Non-Coding Genes

119 genes

# of Chromosomes/Plasmids

Genes

Name	Locus Tag	UniProt	Strand	Coordinates	Molecular Weight
Putative tail fiber repeat family protein	DIP_RS23020	Not Available	+	183877 - 185304	49809.8
hypothetical protein	DIP_RS12485	Not Available	+	185304 - 185978	25238.8
Lysin a	DIP_RS24310	Not Available	+	186059 - 187498	52001.5
Putative holin	DIP_RS12500	Not Available	+	187501 - 187824	11336.7
Membrane protein	DIP_RS12505	Not Available	+	187830 - 188294	16741.9
Hypothetical protein	DIP_RS12510	Not Available	+	188291 - 188629	12166.8
Attr	Not Available	Not Available	+	190741 - 190793	Not Available
Attl	Not Available	Not Available	+	1863158 - 1863169	Not Available
Immunity repressor	DIP_RS23545	Not Available	-	1866365 - 1866670	10850.0
helix-turn-helix transcriptional regulator	DIP_RS20250	Not Available	+	1866762 - 1866953	7018.84

Displaying genes 41 – 50 of 2362 in total

Pathways

227 pathways

2,3-Dihydroxybenzoate Biosynthesis

Biosynthesis of Siderophore Group Nonribosomal Peptides

Lysine Biosynthesis

Glycolysis and Pyruvate Dehydrogenase

Show All 227 Pathways

Metabolite ID	Metabolite name	CAS number	Average mass Monoisotopic mass
BASm0000217	alpha-ribazoleC14H18N2O4	Not available	Average278.3037Da Monoisotopic278.126657074Da
BASm0000237	(R)-4'-phosphopantothenateC9H18NO8P	Not available	Average299.2149Da Monoisotopic299.0770031Da
BASm0000251	2-dehydropantoateC6H9O4	Not available	Average145.1333Da Monoisotopic145.050083776Da
BASm0000377	(S)-malateC4H4O5	Not available	Average132.0716Da Monoisotopic132.005873238Da
BASm0000387	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6	Not available	Average455.432Da Monoisotopic455.1564286Da
BASm0001717	fumarateC4H2O4	Not available	Average114.0563Da Monoisotopic113.9953086Da
BASm0001865	diphosphateHO7P2	Not available	Average174.95Da Monoisotopic174.9213971Da
BASm0001921	(S)-3-methyl-2-oxopentanoateC6H9O3	`1460-34-0`	Average129.1339Da Monoisotopic129.0551692Da
BASm0001971	heptanedioateC7H10O4	Not available	Average158.154Da Monoisotopic158.059006Da
BASm0002305	(S)-2-ethyl-2-hydroxy-3-oxobutanoateC6H9O4	Not available	Average145.135Da Monoisotopic145.0506324Da