Corynebacterium diphtheriae NCTC 13129

Gram-positiveRodNon-motileAerobe

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Mycobacteriales

Family

Corynebacteriaceae

Genus

Corynebacterium

Description

Bacteria from genus Corynebacterium are Gram-positive, nonmotile rods. C.diphtheriae produces the diphtheria toxin, which is usually encoded by a bacteriphage or by an integrated prophage as in this strain. Diphtheria is an acute disease that usually affects the tonsils, throat, nose and/or skin. It is passed from person to person by droplet transmission, usually by breathing in diphtheria bacteria after an infected person has coughed or sneezed. It can lead to breathing problems, heart failure, paralysis and sometimes death. (HAMAP: CORDI)

Taxonomy

Kingdom	Bacillati
Phylum	Actinomycetota
Class	Actinomycetes
Order	Mycobacteriales
Family	Corynebacteriaceae
Genus	Corynebacterium
Species	Corynebacterium diphtheriae
Strain	NCTC 13129

Profile

Physiology
Gram staining properties	Positive
Shape	Rod
Mobility	No
Flagellar presence	Yes
Number of membranes	1

Image source: Wikipedia/Wikimedia

Ecology, Host, and Life Cycle
Oxygen requirements	Aerobe
Optimal temperature	37
Temperature range	Mesophilic
Habitat	Multiple
Biotic relationship	Not Available
Host(s)	Not Available
Cell arrangement	Not Available
Sporulation	Not Available
Energy source	Not Available
Pathogenicity	Yes

Genome Summary

Corynebacterium diphtheriae NCTC 13129

NC_002935.2

Gene Summary

Adenine Count

578357 bp

Thymine Count

579393 bp

Guanine Count

665651 bp

Cytosine Count

665234 bp

Genome Length

2488635 bp

Protein-coding Genes

2243 genes

Non-Coding Genes

119 genes

# of Chromosomes/Plasmids

Genes

Name	Locus Tag	UniProt	Strand	Coordinates	Molecular Weight
Attl	Not Available	Not Available	+	151930 - 151982	Not Available
Hypothetical protein	DIP_RS24625	Not Available	+	154365 - 154994	23923.7
Hypothetical protein	DIP_RS24630	Not Available	+	155099 - 155371	10627.8
Integrase	DIP_RS12315	Not Available	-	155600 - 156826	46253.5
Xre family transcriptional regulator	DIP_RS12320	Not Available	-	156926 - 157948	38275.5
hypothetical protein	DIP_RS12325	Not Available	-	157960 - 158523	21597.8
Peptidase	DIP_RS12330	Not Available	-	158618 - 159025	14490.4
Immunity repressor	DIP_RS12335	Not Available	-	159022 - 159525	18255.8
helix-turn-helix transcriptional regulator	DIP_RS12340	Not Available	+	159645 - 159881	8371.03
hypothetical protein	DIP_RS24140	Not Available	+	159928 - 160395	17490.1

Displaying genes 1 – 10 of 2362 in total

Pathways

227 pathways

2,3-Dihydroxybenzoate Biosynthesis

Biosynthesis of Siderophore Group Nonribosomal Peptides

Lysine Biosynthesis

Glycolysis and Pyruvate Dehydrogenase

Show All 227 Pathways

Metabolite ID	Metabolite name	CAS number	Average mass Monoisotopic mass
BASm0000217	alpha-ribazoleC14H18N2O4	Not available	Average278.3037Da Monoisotopic278.126657074Da
BASm0000237	(R)-4'-phosphopantothenateC9H18NO8P	Not available	Average299.2149Da Monoisotopic299.0770031Da
BASm0000251	2-dehydropantoateC6H9O4	Not available	Average145.1333Da Monoisotopic145.050083776Da
BASm0000377	(S)-malateC4H4O5	Not available	Average132.0716Da Monoisotopic132.005873238Da
BASm0000387	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6	Not available	Average455.432Da Monoisotopic455.1564286Da
BASm0001717	fumarateC4H2O4	Not available	Average114.0563Da Monoisotopic113.9953086Da
BASm0001865	diphosphateHO7P2	Not available	Average174.95Da Monoisotopic174.9213971Da
BASm0001921	(S)-3-methyl-2-oxopentanoateC6H9O3	`1460-34-0`	Average129.1339Da Monoisotopic129.0551692Da
BASm0001971	heptanedioateC7H10O4	Not available	Average158.154Da Monoisotopic158.059006Da
BASm0002305	(S)-2-ethyl-2-hydroxy-3-oxobutanoateC6H9O4	Not available	Average145.135Da Monoisotopic145.0506324Da