Helicobacter pylori strain 22370

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain 22370 is a Gram-negative bacterium characterized by its spiral shape and single-cell arrangement. This microbe thrives optimally at a temperature of 37.0°C, which aligns with its adaptation to the human gastric environment. As a microaerophilic organism, H. pylori strain 22370 requires reduced oxygen levels for growth, reflecting its specialized niche within the host's stomach where oxygen concentrations are lower than in the atmosphere. The habitat of H. pylori strain 22370 is predominantly host-associated, indicating a close relationship with its human host, where it inhabits the gastric mucosa. This unique adaptation allows the bacterium to engage in complex interactions with the host's immune system and gastric environment, contributing to its survival and persistence. Understanding the specific traits of H. pylori strain 22370 enhances our knowledge of its physiological requirements and ecological role within the gastric microbiome. Notably, the microaerophilic nature of this strain may facilitate a distinct metabolic pathway that enables it to thrive in the acidic conditions of the stomach, highlighting the intricate balance of microbial life in host-associated environments. Further research into the metabolic capabilities and interactions of this strain could provide insights into its ecological significance in the human gut microbiome.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain 22370

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain 22370
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain 22370


Gene Summary

Adenine Count

551993 bp

Thymine Count

543878 bp

Guanine Count

349026 bp

Cytosine Count

354017 bp

Genome Length

1798914 bp

Protein-coding Genes

1545 genes

Non-Coding Genes

46 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
dna transfer proteinBB402_00045Not AvailableNegative5745 - 762872416.7
hypothetical proteinBB402_00050Not AvailablePositive7840 - 80647965.54
mechanosensitive ion channel proteinBB402_00055Not AvailablePositive8173 - 899730465.6
5s ribosomal rnaNot AvailableNot AvailablePositive8617 - 8734Not Available
hypothetical proteinBB402_00060Not AvailablePositive9346 - 995123528.3
hypothetical proteinBB402_00065Not AvailablePositive9953 - 1063625460.2
cell division protein ftszBB402_00070Not AvailableNegative10897 - 1205440749.5
cell division protein ftsaBB402_00075Not AvailableNegative12185 - 1366654609.0
peptidylprolyl isomeraseBB402_00080Not AvailableNegative13682 - 1514556421.6
adenosylmethionine--8-amino-7-oxononanoate transaminaseBB402_00085Not AvailablePositive15274 - 1660850347.1

Displaying genes 11 – 20 of 1591 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 66 in total