Burkholderia mallei NCTC 10229

Gram-negativeRodNon-motileAerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Betaproteobacteria

Order

Burkholderiales

Family

Burkholderiaceae

Genus

Burkholderia

Description

Burkholderia mallei is the etiologic agent of glanders, a disease that is often fatal. Its natural reservoir are horses and other equines, but it can be occasionally transmitted to humans either by inhalation or through breaks in the skin. It is an obligate animal pathogen, with an intracellular localization. B. mallei is highly infectious as an aerosol and was used as a biological weapon in the American Civil War and in both World Wars. Unlike the related bacterium B.pseudomallei it is non-motile. One of its virulence factors has been identified as the type III secretion system, another as the newly characterized type VI (T6S). Strain NCTC 10229 will be used for comparative genomics. (EBI Integr8)

Taxonomy

Kingdom	Pseudomonadati
Phylum	Pseudomonadota
Class	Betaproteobacteria
Order	Burkholderiales
Family	Burkholderiaceae
Genus	Burkholderia
Species	Burkholderia mallei
Strain	NCTC 10229

Profile

Physiology
Gram staining properties	Negative
Shape	Rod
Mobility	No
Flagellar presence	Yes
Number of membranes	2

Image source: Wikipedia/Wikimedia

Ecology, Host, and Life Cycle
Oxygen requirements	Aerobe
Optimal temperature	Not Available
Temperature range	Mesophilic
Habitat	HostAssociated
Biotic relationship	Free living
Host(s)	Homo sapiens
Cell arrangement	Not Available
Sporulation	Not Available
Energy source	Not Available
Pathogenicity	Yes

Genome Summary

Burkholderia mallei NCTC 10229

NC_008835.1 NC_008836.1

Gene Summary

Adenine Count

355315 bp

Thymine Count

354120 bp

Guanine Count

788156 bp

Cytosine Count

786504 bp

Genome Length

2284095 bp

Protein-coding Genes

1964 genes

Non-Coding Genes

15 genes

# of Chromosomes/Plasmids

2

Genes

Name	Locus Tag	UniProt	Strand	Coordinates	Molecular Weight
16s ribosomal rna	Not Available	Not Available	+	672 - 2202	Not Available
Trna-ile	Not Available	Not Available	+	2267 - 2343	Not Available
Trna-ala	Not Available	Not Available	+	2378 - 2453	Not Available
23s ribosomal rna	Not Available	Not Available	+	2807 - 5687	Not Available
5s ribosomal rna	Not Available	Not Available	+	5872 - 5985	Not Available
is3-like element is407 family transposase	BMA10229_RS00035	Not Available	-	6230 - 7350	42572.3
glcg/hbps family heme-binding protein	BMA10229_RS00045	Not Available	-	7496 - 7906	13908.7
4fe-4s binding protein	BMA10229_RS00050	Not Available	-	7966 - 9366	51802.8
ftr1 family protein	BMA10229_RS00055	Not Available	-	9363 - 10205	30639.7
cupredoxin domain-containing protein	BMA10229_RS00060	Not Available	-	10265 - 10594	11768.3

Displaying genes 1 – 10 of 5205 in total

Pathways

1458 pathways

2,3-Dihydroxybenzoate Biosynthesis pathway thumbnail

2,3-Dihydroxybenzoate Biosynthesis

2,3-Dihydroxybenzoate Biosynthesis

Biosynthesis of Siderophore Group Nonribosomal Peptides pathway thumbnail

Biosynthesis of Siderophore Group Nonribosomal Peptides

Biosynthesis of Siderophore Group Nonribosomal Peptides

Lysine Biosynthesis pathway thumbnail

Lysine Biosynthesis

Lysine Biosynthesis

Taurine Metabolism pathway thumbnail

Taurine Metabolism

Taurine Metabolism

Glycolysis and Pyruvate Dehydrogenase pathway thumbnail

Glycolysis and Pyruvate Dehydrogenase

Glycolysis and Pyruvate Dehydrogenase

Arginine Metabolism pathway thumbnail

Arginine Metabolism

Arginine Metabolism

Ornithine Metabolism pathway thumbnail

Ornithine Metabolism

Ornithine Metabolism

Proline Metabolism pathway thumbnail

Proline Metabolism

Proline Metabolism

Show All 1458 Pathways

Metabolite ID	Metabolite name	Structure	CAS number	Average mass Monoisotopic mass
BASm0000250	2,5-didehydro-D-gluconateC6H7O7		`53736-12-2`	Average191.1156Da Monoisotopic191.019177578Da
BASm0000253	2-oxopent-4-enoateC5H5O3		Not available	Average113.093Da Monoisotopic113.024417601Da
BASm0000260	3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5		Not available	Average405.556Da Monoisotopic405.264647871Da
BASm0000428	3-oxoadipateC6H6O5		Not available	Average158.11Da Monoisotopic158.022620453Da
BASm0000516	6-deoxyerythronolide BC21H38O6		Not available	Average386.5228Da Monoisotopic386.2668389Da
BASm0000553	biphenyl-2,3-diolC12H10O2		Not available	Average186.2066Da Monoisotopic186.0680796Da
BASm0000592	(S)-1-phenylethanolC8H10O		Not available	Average122.1644Da Monoisotopic122.0731649Da
BASm0000893	crotonobetaineC7H13NO2		`927-89-9`	Average143.1836Da Monoisotopic143.0946287Da
BASm0000989	GlycerolC3H8O3		`56-81-5`	Average92.0938Da Monoisotopic92.04734412Da
BASm0001003	phthalateC8H4O4		Not available	Average164.117Da Monoisotopic164.0120558Da

Displaying 1–10 of 1753 metabolites