Campylobacter lari RM2100

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Campylobacteraceae

Genus

Campylobacter

Description

Campylobacter lari RM2100 is a gram-negative, spiral-shaped bacterium characterized as a microaerophile and a chemoheterotroph, which thrives optimally at temperatures around 42°C. This microorganism is commonly found in various body sites of different species, particularly in the intestines of birds, mammals, and reptiles, where it plays a role in the gut microbiome. As a gram-negative organism, C. lari possesses a thin peptidoglycan layer surrounded by an outer membrane containing lipopolysaccharides, giving it distinctive staining properties. Its spiral shape and motility, facilitated by a single polar flagellum, enable it to navigate the viscous environments of intestinal tracts, contributing to its virulence mechanisms. Microaerophilic in nature, C. lari requires reduced levels of oxygen for optimal growth, making it particularly well-suited to the anaerobic conditions found within the intestines. This oxygen dependency is crucial for its metabolic processes, as it relies on the fermentation of organic compounds as a primary energy source, classifying it as a chemoheterotroph. Notably, C. lari has been associated with gastrointestinal illnesses in humans, particularly through the consumption of contaminated water or undercooked poultry. Its pathogenic potential is underlined by its ability to evade the host immune response and adhere to intestinal epithelial cells, leading to inflammation and infection. Moreover, this microbe has garnered attention in research for its unique genetic and biochemical properties, which may offer insights into the broader Campylobacter genus, paving the way for novel therapeutic approaches to combat Campylobacter-related infections. The study of C. lari RM2100 emphasizes the importance of understanding microbial adaptation and survival strategies within diverse ecological niches.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyCampylobacteraceae
GenusCampylobacter
SpeciesCampylobacter lari
StrainRM2100

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatMultiple
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementChains - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Campylobacter lari RM2100

Accession NumberNC_012040.1

Gene Summary

Adenine Count

17262 bp

Thymine Count

16528 bp

Guanine Count

6516 bp

Cytosine Count

5895 bp

Genome Length

46201 bp

Protein-coding Genes

44 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase hisbCLA_RS00495Not Available+84074 - 8514140547.9
hypothetical proteinCLA_RS00500Not Available+85208 - 8590627691.9
imidazole glycerol phosphate synthase subunit hishCLA_RS00505Not Available+85928 - 8650921599.2
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomeraseCLA_RS00510Not Available+86516 - 8725027051.7
imidazole glycerol phosphate synthase subunit hisfCLA_RS00515Not Available+87232 - 8799928144.1
bifunctional phosphoribosyl-amp cyclohydrolase/phosphoribosyl-atp diphosphatase hisieCLA_RS00520Not Available+88011 - 8863723597.4
methyl-accepting chemotaxis proteinCLA_RS08560Not Available+89264 - 8990523932.2
nyn domain-containing proteinCLA_RS00530Not Available+90252 - 9085723417.5
flagellar hook protein flgeCLA_RS00535Not Available+90993 - 9343786443.9
zeta toxin family proteinCLA_RS00540Not Available-93605 - 9418622672.3

Displaying genes 101 – 110 of 1639 in total

Pathways

9 pathways

Metabolites

21 records
Metabolite IDMetabolite nameStructureCAS number
BASm0003091GDP-4-dehydro-alpha-D-rhamnoseC16H21N5O15P2Chemical structure of GDP-4-dehydro-alpha-D-rhamnoseNot available
Average585.313Da
Monoisotopic585.052036152Da
BASm0003656N-acetyl-beta-D-muramate 6-phosphateC11H17NO11PChemical structure of N-acetyl-beta-D-muramate 6-phosphateNot available
Average370.228Da
Monoisotopic370.0555681Da
BASm00041244-(gamma-L-glutamylamino)butanalC9H16N2O4Chemical structure of 4-(gamma-L-glutamylamino)butanalNot available
Average216.2343Da
Monoisotopic216.11100701Da
BASm0004924UDP-N-acetyl-alpha-D-mannosaminouronateC17H22N3O18P2Chemical structure of UDP-N-acetyl-alpha-D-mannosaminouronateNot available
Average618.3134Da
Monoisotopic618.037358939Da
BASm0004925UDP-N-acetyl-alpha-D-muramateC20H28N3O19P2Chemical structure of UDP-N-acetyl-alpha-D-muramateNot available
Average676.395Da
Monoisotopic676.080870429Da
BASm0014032Acetic acidC2H4O2Chemical structure of Acetic acid64-19-7
Average60.052Da
Monoisotopic60.021129372Da
BASm0014033AmmoniaH3NChemical structure of Ammonia7664-41-7
Average17.0305Da
Monoisotopic17.026549101Da
BASm0014042Oxoglutaric acidC5H6O5Chemical structure of Oxoglutaric acid328-50-7
Average146.0981Da
Monoisotopic146.021523302Da
BASm0017263NADPC21H29N7O17P3Chemical structure of NADP53-59-8
Average744.4129Da
Monoisotopic744.083277073Da
BASm0017265Uridine diphosphate-N-acetylglucosamineC17H27N3O17P2Chemical structure of Uridine diphosphate-N-acetylglucosamine528-04-1
Average607.3537Da
Monoisotopic607.081569477Da

Displaying 1–10 of 21 metabolites