Burkholderia mallei ATCC 23344

Gram-negativeRodNon-motileAerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Betaproteobacteria

Order

Burkholderiales

Family

Burkholderiaceae

Genus

Burkholderia

Description

Burkholderia mallei is the etiologic agent of glanders, a disease that is often fatal. Its natural reservoir are horses and other equines, but it can be occasionally transmitted to humans either by inhalation or through breaks in the skin. It is an obligate animal pathogen, with an intracellular localization. B. mallei is highly infectious as an aerosol and was used as a biological weapon in the American Civil War and in both World Wars. Unlike the related bacterium B.pseudomallei it is non-motile. One of its virulence factors has been identified as the type III secretion system, another as the newly characterized type VI (T6S). Strain NCTC 10229 will be used for comparative genomics. (EBI Integr8)

Taxonomy

Kingdom	Pseudomonadati
Phylum	Pseudomonadota
Class	Betaproteobacteria
Order	Burkholderiales
Family	Burkholderiaceae
Genus	Burkholderia
Species	Burkholderia mallei
Strain	ATCC 23344

Profile

Physiology
Gram staining properties	Negative
Shape	Rod
Mobility	No
Flagellar presence	Yes
Number of membranes	2

Ecology, Host, and Life Cycle
Oxygen requirements	Aerobe
Optimal temperature	Not Available
Temperature range	Mesophilic
Habitat	HostAssociated
Biotic relationship	Free living
Host(s)	Homo sapiens
Cell arrangement	Not Available
Sporulation	Not Available
Energy source	Not Available
Pathogenicity	Yes

Genome Summary

Burkholderia mallei ATCC 23344

Accession NumberNC_006348.1

Gene Summary

Adenine Count

559281 bp

Thymine Count

558552 bp

Guanine Count

1185888 bp

Cytosine Count

1206427 bp

Genome Length

3510148 bp

Protein-coding Genes

3222 genes

Non-Coding Genes

55 genes

# of Chromosomes/Plasmids

2

Genes

Name	Locus Tag	UniProt	Strand	Coordinates	Molecular Weight
hypothetical protein	BMA_RS00045	Not Available	+	17746 - 18072	12206.8
hypothetical protein	BMA_RS00050	Not Available	-	18354 - 18695	11671.0
hypothetical protein	BMA_RS00055	Not Available	-	18755 - 19132	13242.9
hypothetical protein	BMA_RS00060	Not Available	-	19419 - 19793	13701.5
hypothetical protein	BMA_RS00065	Not Available	-	20034 - 20279	9022.68
hypothetical protein	BMA_RS00070	Not Available	-	20276 - 20629	12924.5
fha domain-containing protein	BMA_RS00075	Not Available	+	20898 - 21896	35992.8
tomm system kinase/cyclase fusion protein	BMA_RS00080	Not Available	+	21907 - 25986	145240.0
bma_0021/bma_0022 family tomm bacteriocin	BMA_RS00085	Not Available	+	25983 - 26345	13646.2
bma_0021/bma_0022 family tomm bacteriocin	BMA_RS00090	Not Available	+	26347 - 26709	13771.3

Displaying genes 11 – 20 of 5292 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolite ID	Metabolite name	Structure	CAS number	Average mass Monoisotopic mass
BASm0000198	tetracenomycin CC23H20O11		Not available	Average472.402Da Monoisotopic472.100561464Da
BASm0000217	alpha-ribazoleC14H18N2O4		Not available	Average278.3037Da Monoisotopic278.126657074Da
BASm0000237	(R)-4'-phosphopantothenateC9H18NO8P		Not available	Average299.2149Da Monoisotopic299.0770031Da
BASm0000238	(R)-3-phenyllactateC9H9O3		Not available	Average165.169Da Monoisotopic165.05571773Da
BASm0000250	2,5-didehydro-D-gluconateC6H7O7		`53736-12-2`	Average191.1156Da Monoisotopic191.019177578Da
BASm0000251	2-dehydropantoateC6H9O4		Not available	Average145.1333Da Monoisotopic145.050083776Da
BASm0000253	2-oxopent-4-enoateC5H5O3		Not available	Average113.093Da Monoisotopic113.024417601Da
BASm0000254	3-hydroxy-2-methylpropanoateC4H7O3		Not available	Average103.098Da Monoisotopic103.0400677Da
BASm0000272	(E)-4-coumarateC9H7O3		Not available	Average163.1501Da Monoisotopic163.0395191Da
BASm0000277	keto-L-sorboseC6H12O6		Not available	Average180.1559Da Monoisotopic180.0633881Da

Displaying 1–10 of 479 metabolites