Haemophilus influenzae Rd KW20

Gram-negativeRodNon-motileAerobe; facultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae Rd KW20 is a Gram-negative, rod-shaped bacterium that thrives optimally at a temperature of 35-37 °C. As a chemoheterotroph, it derives its energy from organic compounds, relying on the organic matter present in its environment for growth. This microbe is primarily found in the human respiratory tract, specifically in the nasopharynx and can also be isolated from various other body sites, including the ears, lungs, and sinuses. Classified as a facultative anaerobe, it can live in both aerobic and anaerobic conditions, making it adaptable to a range of environments within the host. H. influenzae Rd KW20 is notable for its role in human health; while it is part of the normal flora of the upper respiratory tract in healthy individuals, it can become pathogenic under certain circumstances. It is known to cause a range of infections, including pneumonia, sinusitis, and otitis media, particularly in children and immunocompromised adults.As a strain in the study of bacterial genetics, H. influenzae Rd KW20 has contributed to significant advancements in the understanding of molecular biology and genetics. Remarkably, it was one of the first organisms to have its genome completely sequenced, providing valuable insights into bacterial evolution, pathogenic mechanisms, and antibiotic resistance. Moreover, its relatively simple genetic makeup makes it an ideal model organism for laboratory studies, facilitating research in areas such as gene expression, protein function, and microbial interactions within the host.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
StrainRd KW20

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae Rd KW20
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe; facultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityYes

Genome Summary

Haemophilus influenzae Rd KW20

Accession NumberNC_000907.1

Gene Summary

Adenine Count

567623 bp

Thymine Count

564241 bp

Guanine Count

347436 bp

Cytosine Count

350723 bp

Genome Length

1830138 bp

Protein-coding Genes

1663 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
AttlNot AvailableNot Available+1495049 - 1495060Not Available
Tail fibersHI_RS07250P44178-1499076 - 149962420537.4
Hypothetical proteinHI_RS07255P44179-1499657 - 150010916923.3
Gp27 putative head proteinHI_RS07260P44180-1500122 - 150122240124.3
Hypothetical proteinHI_RS07265P44181-1501283 - 150163913326.1
Putative minor head proteinHI_RS07270P71385-1501918 - 150334452500.5
Putative portal proteinHI_RS07275P44183-1503394 - 150470448923.7
pbsx family phage terminase large subunitHI_RS07280Not Available-1504706 - 150604849912.1
Putative terminase small subunitHI_RS07285Q57374-1506035 - 150655018966.7
Conserved hypothetical proteinHI_RS07290P45197-1506560 - 150708120513.1

Displaying genes 1 – 10 of 3606 in total

Pathways

25 pathways

Metabolites

188 records
Metabolite IDMetabolite nameStructureCAS number
BASm00037365-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylateC14H13O9Chemical structure of 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylateNot available
Average325.251Da
Monoisotopic325.057602738Da
BASm0003763(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphateC11H12NO6PChemical structure of (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphateNot available
Average285.1898Da
Monoisotopic285.0402236Da
BASm00037841,4-dihydroxy-2-naphthoyl-CoAC32H38N7O19P3SChemical structure of 1,4-dihydroxy-2-naphthoyl-CoANot available
Average949.67Da
Monoisotopic949.117798519Da
BASm0003841N-[(R)-4-phosphopantothenoyl]-L-cysteineC12H20N2O9PSChemical structure of N-[(R)-4-phosphopantothenoyl]-L-cysteineNot available
Average399.33Da
Monoisotopic399.064359144Da
BASm0003896ADP-D-glycero-beta-D-manno-heptoseC17H25N5O16P2Chemical structure of ADP-D-glycero-beta-D-manno-heptoseNot available
Average617.355Da
Monoisotopic617.078250901Da
BASm0003971heme bC34H30FeN4O4Not available14875-96-8
Average614.484Da
Monoisotopic614.162739Da
BASm0003983di-trans,octa-cis-undecaprenyl phosphateC55H89O4PChemical structure of di-trans,octa-cis-undecaprenyl phosphateNot available
Average845.288Da
Monoisotopic844.6509455Da
BASm00040892'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoAC26H40N7O26P5SChemical structure of 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoANot available
Average1053.56Da
Monoisotopic1053.046472079Da
BASm0004092UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineC41H61N9O28P2Chemical structure of UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineNot available
Average1189.924Da
Monoisotopic1189.312320676Da
BASm0004093di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineC87H139N7O23P2Chemical structure of di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanineNot available
Average1713.045Da
Monoisotopic1711.941952079Da

Displaying 61–70 of 188 metabolites