Haemophilus influenzae Rd KW20

Gram-negativeRodNon-motileAerobe; facultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae Rd KW20 is a Gram-negative, rod-shaped bacterium that thrives optimally at a temperature of 35-37 °C. As a chemoheterotroph, it derives its energy from organic compounds, relying on the organic matter present in its environment for growth. This microbe is primarily found in the human respiratory tract, specifically in the nasopharynx and can also be isolated from various other body sites, including the ears, lungs, and sinuses. Classified as a facultative anaerobe, it can live in both aerobic and anaerobic conditions, making it adaptable to a range of environments within the host. H. influenzae Rd KW20 is notable for its role in human health; while it is part of the normal flora of the upper respiratory tract in healthy individuals, it can become pathogenic under certain circumstances. It is known to cause a range of infections, including pneumonia, sinusitis, and otitis media, particularly in children and immunocompromised adults.As a strain in the study of bacterial genetics, H. influenzae Rd KW20 has contributed to significant advancements in the understanding of molecular biology and genetics. Remarkably, it was one of the first organisms to have its genome completely sequenced, providing valuable insights into bacterial evolution, pathogenic mechanisms, and antibiotic resistance. Moreover, its relatively simple genetic makeup makes it an ideal model organism for laboratory studies, facilitating research in areas such as gene expression, protein function, and microbial interactions within the host.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
StrainRd KW20

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae Rd KW20
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe; facultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityYes

Genome Summary

Haemophilus influenzae Rd KW20

Accession NumberNC_000907.1

Gene Summary

Adenine Count

567623 bp

Thymine Count

564241 bp

Guanine Count

347436 bp

Cytosine Count

350723 bp

Genome Length

1830138 bp

Protein-coding Genes

1663 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
AttlNot AvailableNot Available+1495049 - 1495060Not Available
Tail fibersHI_RS07250P44178-1499076 - 149962420537.4
Hypothetical proteinHI_RS07255P44179-1499657 - 150010916923.3
Gp27 putative head proteinHI_RS07260P44180-1500122 - 150122240124.3
Hypothetical proteinHI_RS07265P44181-1501283 - 150163913326.1
Putative minor head proteinHI_RS07270P71385-1501918 - 150334452500.5
Putative portal proteinHI_RS07275P44183-1503394 - 150470448923.7
pbsx family phage terminase large subunitHI_RS07280Not Available-1504706 - 150604849912.1
Putative terminase small subunitHI_RS07285Q57374-1506035 - 150655018966.7
Conserved hypothetical proteinHI_RS07290P45197-1506560 - 150708120513.1

Displaying genes 1 – 10 of 3606 in total

Pathways

25 pathways

Metabolites

188 records
Metabolite IDMetabolite nameStructureCAS number
BASm00034715-amino-6-(5-phospho-D-ribosylamino)uracilC9H13N4O9PChemical structure of 5-amino-6-(5-phospho-D-ribosylamino)uracilNot available
Average352.197Da
Monoisotopic352.0431122Da
BASm0003491(2S)-2-acetolactateC5H7O4Chemical structure of (2S)-2-acetolactateNot available
Average131.108Da
Monoisotopic131.0349823Da
BASm00034972-C-methyl-D-erythritol 2,4-cyclic diphosphateC5H10O9P2Chemical structure of 2-C-methyl-D-erythritol 2,4-cyclic diphosphate143488-44-2
Average276.075Da
Monoisotopic275.9800049Da
BASm00035255-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideC15H21N5O15P2Chemical structure of 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideNot available
Average573.303Da
Monoisotopic573.0531333Da
BASm0003537(R)-3-hydroxy-2-oxo-4-phosphooxybutanoateC4H4O8PChemical structure of (R)-3-hydroxy-2-oxo-4-phosphooxybutanoateNot available
Average211.043Da
Monoisotopic210.9660248Da
BASm0003631(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylateC11H10O6Chemical structure of (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylateNot available
Average238.196Da
Monoisotopic238.0488352Da
BASm0003644N-acetyl-beta-neuraminateC11H18NO9Chemical structure of N-acetyl-beta-neuraminateNot available
Average308.264Da
Monoisotopic308.0987047Da
BASm0003657N-acetyl-D-muramate 6-phosphateC11H17NO11PChemical structure of N-acetyl-D-muramate 6-phosphateNot available
Average370.228Da
Monoisotopic370.0555681Da
BASm00036917,8-dihydroneopterin 3'-phosphateC9H12N5O7PChemical structure of 7,8-dihydroneopterin 3'-phosphateNot available
Average333.1946Da
Monoisotopic333.047434275Da
BASm0003701L-methionine (S)-S-oxideC5H11NO3SChemical structure of L-methionine (S)-S-oxide62697-73-8
Average165.21Da
Monoisotopic165.045964392Da

Displaying 51–60 of 188 metabolites