Haemophilus influenzae Rd KW20

Gram-negativeRodNon-motileAerobe; facultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae Rd KW20 is a Gram-negative, rod-shaped bacterium that thrives optimally at a temperature of 35-37 °C. As a chemoheterotroph, it derives its energy from organic compounds, relying on the organic matter present in its environment for growth. This microbe is primarily found in the human respiratory tract, specifically in the nasopharynx and can also be isolated from various other body sites, including the ears, lungs, and sinuses. Classified as a facultative anaerobe, it can live in both aerobic and anaerobic conditions, making it adaptable to a range of environments within the host. H. influenzae Rd KW20 is notable for its role in human health; while it is part of the normal flora of the upper respiratory tract in healthy individuals, it can become pathogenic under certain circumstances. It is known to cause a range of infections, including pneumonia, sinusitis, and otitis media, particularly in children and immunocompromised adults.As a strain in the study of bacterial genetics, H. influenzae Rd KW20 has contributed to significant advancements in the understanding of molecular biology and genetics. Remarkably, it was one of the first organisms to have its genome completely sequenced, providing valuable insights into bacterial evolution, pathogenic mechanisms, and antibiotic resistance. Moreover, its relatively simple genetic makeup makes it an ideal model organism for laboratory studies, facilitating research in areas such as gene expression, protein function, and microbial interactions within the host.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
StrainRd KW20

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae Rd KW20
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe; facultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityYes

Genome Summary

Haemophilus influenzae Rd KW20

Accession NumberNC_000907.1

Gene Summary

Adenine Count

567623 bp

Thymine Count

564241 bp

Guanine Count

347436 bp

Cytosine Count

350723 bp

Genome Length

1830138 bp

Protein-coding Genes

1663 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
transcriptional regulatorHI_RS07695P44216+1568867 - 156930016805.6
hypothetical proteinHI_RS07700P44217+1569309 - 156981519213.6
Putative n-acetylmuramoyl-l-alanine amidaseHI_RS07705P44218+1569897 - 157044119915.6
Hypothetical proteinHI_RS07710P44219+1570448 - 15707089464.15
duf2681 domain-containing proteinHI_RS07715P44220+1570705 - 15709599773.83
trar/dksa family transcriptional regulatorHI_RS07720P44221+1571077 - 15713048405.74
duf2730 domain-containing proteinHI_RS07725P44222+1571304 - 157163012161.7
Hypothetical proteinHI_RS07730O86242+1571635 - 157194311648.9
Hypothetical proteinHI_RS07735P44223+1571955 - 157252421017.3
Portal proteinHI_RS07740P44224+1572524 - 157405057193.9

Displaying genes 41 – 50 of 3606 in total

Pathways

25 pathways

Metabolites

188 records
Metabolite IDMetabolite nameStructureCAS number
BASm0017461PS(14:0/16:0)C36H70NO10PChemical structure of PS(14:0/16:0)NULL
Average707.927Da
Monoisotopic707.473734456Da
BASm0017610N-Acetylmuramate 6-phosphateC11H19NO11PChemical structure of N-Acetylmuramate 6-phosphateNULL
Average372.2424Da
Monoisotopic372.069571967Da
BASm0017691PS(14:0/18:1(11Z))C38H72NO10PChemical structure of PS(14:0/18:1(11Z))NULL
Average733.965Da
Monoisotopic733.48938452Da
BASm0017743Stearoyl-CoAC39H70N7O17P3SChemical structure of Stearoyl-CoA362-66-3
Average1033.996Da
Monoisotopic1033.376174075Da
BASm0017775PE(12:0/14:0)C31H62NO8PChemical structure of PE(12:0/14:0)NULL
Average607.81Da
Monoisotopic607.421304958Da
BASm0017777PE(12:0/16:0)C33H66NO8PChemical structure of PE(12:0/16:0)NULL
Average635.864Da
Monoisotopic635.452605087Da
BASm0017778PE(12:0/16:1(9Z))C33H64NO8PChemical structure of PE(12:0/16:1(9Z))NULL
Average633.848Da
Monoisotopic633.436955023Da
BASm0017781PE(12:0/18:1(11Z))C35H68NO8PChemical structure of PE(12:0/18:1(11Z))NULL
Average661.902Da
Monoisotopic661.468255152Da
BASm0018523CDP-DG(12:0/14:0)C38H69N3O15P2Chemical structure of CDP-DG(12:0/14:0)NULL
Average869.924Da
Monoisotopic869.42039253Da
BASm0018525CDP-DG(12:0/16:0)C40H73N3O15P2Chemical structure of CDP-DG(12:0/16:0)NULL
Average897.978Da
Monoisotopic897.451692659Da

Displaying 121–130 of 188 metabolites