Haemophilus influenzae Rd KW20

Gram-negativeRodNon-motileAerobe; facultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae Rd KW20 is a Gram-negative, rod-shaped bacterium that thrives optimally at a temperature of 35-37 °C. As a chemoheterotroph, it derives its energy from organic compounds, relying on the organic matter present in its environment for growth. This microbe is primarily found in the human respiratory tract, specifically in the nasopharynx and can also be isolated from various other body sites, including the ears, lungs, and sinuses. Classified as a facultative anaerobe, it can live in both aerobic and anaerobic conditions, making it adaptable to a range of environments within the host. H. influenzae Rd KW20 is notable for its role in human health; while it is part of the normal flora of the upper respiratory tract in healthy individuals, it can become pathogenic under certain circumstances. It is known to cause a range of infections, including pneumonia, sinusitis, and otitis media, particularly in children and immunocompromised adults.As a strain in the study of bacterial genetics, H. influenzae Rd KW20 has contributed to significant advancements in the understanding of molecular biology and genetics. Remarkably, it was one of the first organisms to have its genome completely sequenced, providing valuable insights into bacterial evolution, pathogenic mechanisms, and antibiotic resistance. Moreover, its relatively simple genetic makeup makes it an ideal model organism for laboratory studies, facilitating research in areas such as gene expression, protein function, and microbial interactions within the host.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
StrainRd KW20

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae Rd KW20
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe; facultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityYes

Genome Summary

Haemophilus influenzae Rd KW20

Accession NumberNC_000907.1

Gene Summary

Adenine Count

567623 bp

Thymine Count

564241 bp

Guanine Count

347436 bp

Cytosine Count

350723 bp

Genome Length

1830138 bp

Protein-coding Genes

1663 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
AttrNot AvailableNot Available+1511793 - 1511804Not Available
hypothetical proteinHI_RS07340P44194+1511874 - 151215810657.9
IntegraseHI_RS07345P45198-1512159 - 151307334858.4
Gp245HI_RS07620Q57213-1558774 - 155937322738.4
abc transporter permease subunitHI_RS07625Q57380-1559375 - 155972212781.0
Transcription regulatorHI_RS07630P44207-1559962 - 156068126669.5
Mu-like prophage flumu dna-binding protein nerHI_RS07635P46496+1560909 - 156117810262.4
TransposaseHI_RS07640O05069+1561212 - 156327578613.2
dna-binding domain-containing proteinHI_RS07645P44208+1563332 - 156360410467.7
hypothetical proteinHI_RS07650P44209-1563537 - 156400717736.5

Displaying genes 21 – 30 of 3606 in total

Pathways

25 pathways

Metabolites

188 records
Metabolite IDMetabolite nameStructureCAS number
BASm0020176PE(14:1(9Z)/16:0)C35H68NO8PChemical structure of PE(14:1(9Z)/16:0)NULL
Average661.8901Da
Monoisotopic661.468254669Da
BASm0020207PS(12:0/16:0)C34H66NO10PChemical structure of PS(12:0/16:0)NULL
Average679.8623Da
Monoisotopic679.442433849Da
BASm0020208PS(12:0/16:1(9Z))C34H64NO10PChemical structure of PS(12:0/16:1(9Z))NULL
Average677.8464Da
Monoisotopic677.426783785Da
BASm0020209PS(14:1(9Z)/16:0)C36H68NO10PChemical structure of PS(14:1(9Z)/16:0)NULL
Average705.8996Da
Monoisotopic705.458083913Da
BASm0030785CDP-DG(12:0/18:1(11Z))C42H75N3O15P2Chemical structure of CDP-DG(12:0/18:1(11Z))NULL
Average924.016Da
Monoisotopic923.467342723Da
BASm0030809CDP-DG(14:0/18:1(11Z))C44H79N3O15P2Chemical structure of CDP-DG(14:0/18:1(11Z))NULL
Average952.07Da
Monoisotopic951.498642852Da
BASm0030858CDP-DG(14:1(9Z)/16:0)C42H75N3O15P2Chemical structure of CDP-DG(14:1(9Z)/16:0)NULL
Average924.016Da
Monoisotopic923.467342723Da
BASm0031891LPA(12:0/0:0)C15H31O7PChemical structure of LPA(12:0/0:0)NULL
Average354.38Da
Monoisotopic354.180740336Da
BASm0031892LPA(14:0/0:0)C17H35O7PChemical structure of LPA(14:0/0:0)NULL
Average382.434Da
Monoisotopic382.212040465Da
BASm0031894LPA(14:1(9Z)/0:0)C17H33O7PChemical structure of LPA(14:1(9Z)/0:0)NULL
Average380.418Da
Monoisotopic380.196390401Da

Displaying 171–180 of 188 metabolites