Haemophilus influenzae Rd KW20

Gram-negativeRodNon-motileAerobe; facultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae Rd KW20 is a Gram-negative, rod-shaped bacterium that thrives optimally at a temperature of 35-37 °C. As a chemoheterotroph, it derives its energy from organic compounds, relying on the organic matter present in its environment for growth. This microbe is primarily found in the human respiratory tract, specifically in the nasopharynx and can also be isolated from various other body sites, including the ears, lungs, and sinuses. Classified as a facultative anaerobe, it can live in both aerobic and anaerobic conditions, making it adaptable to a range of environments within the host. H. influenzae Rd KW20 is notable for its role in human health; while it is part of the normal flora of the upper respiratory tract in healthy individuals, it can become pathogenic under certain circumstances. It is known to cause a range of infections, including pneumonia, sinusitis, and otitis media, particularly in children and immunocompromised adults.As a strain in the study of bacterial genetics, H. influenzae Rd KW20 has contributed to significant advancements in the understanding of molecular biology and genetics. Remarkably, it was one of the first organisms to have its genome completely sequenced, providing valuable insights into bacterial evolution, pathogenic mechanisms, and antibiotic resistance. Moreover, its relatively simple genetic makeup makes it an ideal model organism for laboratory studies, facilitating research in areas such as gene expression, protein function, and microbial interactions within the host.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
StrainRd KW20

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae Rd KW20
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe; facultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityYes

Genome Summary

Haemophilus influenzae Rd KW20

Accession NumberNC_000907.1

Gene Summary

Adenine Count

567623 bp

Thymine Count

564241 bp

Guanine Count

347436 bp

Cytosine Count

350723 bp

Genome Length

1830138 bp

Protein-coding Genes

1663 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
Putative lytic protein rz1HI_RS07295P44185-1507209 - 150749010360.7
Putative lytic protein rzHI_RS07300P44186-1507402 - 150767710343.4
Putative lys proteinHI_RS07305P44187-1507670 - 150827222896.5
HolinHI_RS07310P44188-1508241 - 150859713516.4
hypothetical proteinHI_RS08995Not Available-1508721 - 15088585041.05
Possible bacteriophage antirepressorHI_RS07315P44189-1508934 - 150960125580.6
Addiction module antitoxin/toxinHI_RS07320P44190+1509962 - 151026111169.7
Gp6, putative addiction module antidote proteinHI_RS07325P44191+1510258 - 151055110890.0
hypothetical proteinHI_RS07330P44192-1510582 - 151094414134.2
AntirepressorHI_RS07335P44193+1511013 - 151158822702.4

Displaying genes 11 – 20 of 3606 in total

Pathways

25 pathways

Metabolites

188 records
Metabolite IDMetabolite nameStructureCAS number
BASm00087712-dehydro-D-erythronateC4H5O5Chemical structure of 2-dehydro-D-erythronateNot available
Average133.08Da
Monoisotopic133.0142468Da
BASm00087722-dehydro-L-erythronateC4H5O5Chemical structure of 2-dehydro-L-erythronateNot available
Average133.08Da
Monoisotopic133.0142468Da
BASm00087733-dehydro-L-erythronateC4H5O5Chemical structure of 3-dehydro-L-erythronateNot available
Average133.08Da
Monoisotopic133.0142468Da
BASm0009321beta-D-fructose 1-phosphateC6H11O9PChemical structure of beta-D-fructose 1-phosphateNot available
Average258.12Da
Monoisotopic258.015166092Da
BASm0010316N(1)-(5-phospho-beta-D-ribosyl)glycinamideC7H14N2O8PChemical structure of N(1)-(5-phospho-beta-D-ribosyl)glycinamideNot available
Average285.169Da
Monoisotopic285.049326Da
BASm00106538-oxo-GMPC10H12N5O9PChemical structure of 8-oxo-GMPNot available
Average377.207Da
Monoisotopic377.038361144Da
BASm00107383-phosphoshikimateC7H8O8PChemical structure of 3-phosphoshikimateNot available
Average251.108Da
Monoisotopic250.997324955Da
BASm0010758N(4)-acetyl-2'-deoxycytidineC11H15N3O5Chemical structure of N(4)-acetyl-2'-deoxycytidineNot available
Average269.257Da
Monoisotopic269.101170595Da
BASm0010759N(4)-acetylcytosineC6H7N3O2Chemical structure of N(4)-acetylcytosineNot available
Average153.141Da
Monoisotopic153.053826477Da
BASm0010825N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamideC8H13N2O9PChemical structure of N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamideNot available
Average312.172Da
Monoisotopic312.0369642Da

Displaying 91–100 of 188 metabolites