Haemophilus influenzae Rd KW20

Gram-negativeRodNon-motileAerobe; facultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae Rd KW20 is a Gram-negative, rod-shaped bacterium that thrives optimally at a temperature of 35-37 °C. As a chemoheterotroph, it derives its energy from organic compounds, relying on the organic matter present in its environment for growth. This microbe is primarily found in the human respiratory tract, specifically in the nasopharynx and can also be isolated from various other body sites, including the ears, lungs, and sinuses. Classified as a facultative anaerobe, it can live in both aerobic and anaerobic conditions, making it adaptable to a range of environments within the host. H. influenzae Rd KW20 is notable for its role in human health; while it is part of the normal flora of the upper respiratory tract in healthy individuals, it can become pathogenic under certain circumstances. It is known to cause a range of infections, including pneumonia, sinusitis, and otitis media, particularly in children and immunocompromised adults.As a strain in the study of bacterial genetics, H. influenzae Rd KW20 has contributed to significant advancements in the understanding of molecular biology and genetics. Remarkably, it was one of the first organisms to have its genome completely sequenced, providing valuable insights into bacterial evolution, pathogenic mechanisms, and antibiotic resistance. Moreover, its relatively simple genetic makeup makes it an ideal model organism for laboratory studies, facilitating research in areas such as gene expression, protein function, and microbial interactions within the host.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
StrainRd KW20

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae Rd KW20
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe; facultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityYes

Genome Summary

Haemophilus influenzae Rd KW20

Accession NumberNC_000907.1

Gene Summary

Adenine Count

567623 bp

Thymine Count

564241 bp

Guanine Count

347436 bp

Cytosine Count

350723 bp

Genome Length

1830138 bp

Protein-coding Genes

1663 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
AttlNot AvailableNot Available+1495049 - 1495060Not Available
Tail fibersHI_RS07250P44178-1499076 - 149962420537.4
Hypothetical proteinHI_RS07255P44179-1499657 - 150010916923.3
Gp27 putative head proteinHI_RS07260P44180-1500122 - 150122240124.3
Hypothetical proteinHI_RS07265P44181-1501283 - 150163913326.1
Putative minor head proteinHI_RS07270P71385-1501918 - 150334452500.5
Putative portal proteinHI_RS07275P44183-1503394 - 150470448923.7
pbsx family phage terminase large subunitHI_RS07280Not Available-1504706 - 150604849912.1
Putative terminase small subunitHI_RS07285Q57374-1506035 - 150655018966.7
Conserved hypothetical proteinHI_RS07290P45197-1506560 - 150708120513.1

Displaying genes 1 – 10 of 3606 in total

Pathways

25 pathways

Metabolites

188 records
Metabolite IDMetabolite nameStructureCAS number
BASm0007003UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioateC35H51N7O26P2Chemical structure of UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioateNot available
Average1047.7583Da
Monoisotopic1047.235898Da
BASm00074603-deoxy-alpha-D-manno-2-octulosonate-8-phosphateC8H12O11PChemical structure of 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphateNot available
Average315.148Da
Monoisotopic315.0133689Da
BASm00074613-deoxy-alpha-D-manno-oct-2-ulosonateC8H13O8Chemical structure of 3-deoxy-alpha-D-manno-oct-2-ulosonateNot available
Average237.185Da
Monoisotopic237.061591Da
BASm0007980reduced beta-nicotinamide D-ribonucleotideC11H15N2O8PChemical structure of reduced beta-nicotinamide D-ribonucleotideNot available
Average334.222Da
Monoisotopic334.0576996Da
BASm0008099(2E)-4-hydroxy-3-methylbut-2-enyl diphosphateC5H9O8P2Chemical structure of (2E)-4-hydroxy-3-methylbut-2-enyl diphosphateNot available
Average259.0677Da
Monoisotopic258.9772653Da
BASm0008132(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateC10H12N5O14P3Chemical structure of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateNot available
Average519.15Da
Monoisotopic518.9615554Da
BASm0008580carboxy-S-adenosyl-L-methionineC16H22N6O7SChemical structure of carboxy-S-adenosyl-L-methionineNot available
Average442.45Da
Monoisotopic442.1270682Da
BASm0008749D-erythronateC4H7O5Chemical structure of D-erythronateNot available
Average135.096Da
Monoisotopic135.0298969Da
BASm00087503-dehydro-4-O-phospho-L-erythronateC4H4O8PChemical structure of 3-dehydro-4-O-phospho-L-erythronateNot available
Average211.043Da
Monoisotopic210.9660248Da
BASm00087513-dehydro-4-O-phospho-D-erythronateC4H4O8PChemical structure of 3-dehydro-4-O-phospho-D-erythronateNot available
Average211.043Da
Monoisotopic210.9660248Da

Displaying 81–90 of 188 metabolites